http://sepresa.bio-x.cn/ a Server for the Prediction of Population Susceptible to Serious Adverse Drug Reaction http://www.pdb.org/pdb/explore/explore.do?structureId=2PM8 Adverse Drug Reaction: Inhibition by cyclophosphamide: reduces or slows cocaine metabolism, thereby increasing and/or prolonging its effects and increasing the risk of toxicity | Inhibition of chlorpyrifos: Developmental neurotoxicity.
Protein Name: Cholinesterase
Gene Name: BCHE]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1XWG Adverse Drug Reaction: Change in the capacity of drug metabolism
Protein Name: Glutathione S-transferase A1
Gene Name: GSTA1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1GTU Adverse Drug Reaction: Change in the capacity of drug metabolism
Protein Name: Glutathione S-transferase Mu 1
Gene Name: GSTM1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1R9O Adverse Drug Reaction: Inhibition: dose-dependent toxicity;Haemorrhage, Hypoglycaemia, Phenytoin toxicity
Protein Name: Cytochrome P450 2C9
Gene Name: CYP2C9]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1OG5 Adverse Drug Reaction: Inhibition: dose-dependent toxicity;Haemorrhage, Hypoglycaemia, Phenytoin toxicity
Protein Name: Cytochrome P450 2C9
Gene Name: CYP2C9]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2Z5Y Adverse Drug Reaction: Change in the capacity of drug metabolism
Protein Name: Amine oxidase [flavin-containing] A
Gene Name: MAOA]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1V04 Adverse Drug Reaction: Change in the capacity of drug metabolism
Protein Name: Serum paraoxonase/arylesterase 1
Gene Name: PON1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1GOS Adverse Drug Reaction: Change in the capacity of drug metabolism
Protein Name: Amine oxidase [flavin-containing] B
Gene Name: MAOB]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2AB6 Adverse Drug Reaction: Change in the capacity of drug metabolism
Protein Name: Glutathione S-transferase Mu 2
Gene Name: GSTM2]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2C3T Adverse Drug Reaction: Change in the capacity of drug metabolism
Protein Name: Glutathione S-transferase theta-1
Gene Name: GSTT1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1G3M Adverse Drug Reaction: Change in the capacity of drug metabolism
Protein Name: Estrogen sulfotransferase
Gene Name: SULT1E1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1JQE Adverse Drug Reaction: Change in the capacity of drug metabolism
Protein Name: Histamine N-methyltransferase
Gene Name: HNMT]]> http://www.pdb.org/pdb/explore/explore.do?structureId=4GTU Adverse Drug Reaction: Change in the capacity of drug metabolism
Protein Name: Glutathione S-transferase Mu 4
Gene Name: GSTM4]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1EFH Adverse Drug Reaction: Change in the capacity of drug metabolism
Protein Name: Bile salt sulfotransferase
Gene Name: SULT2A1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1VCU Adverse Drug Reaction: neuropsychiatric disorders
Protein Name: Sialidase-2
Gene Name: NEU2]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2H11 Adverse Drug Reaction: Change in the capacity of drug metabolism
Protein Name: Thiopurine S-methyltransferase
Gene Name: TPMT]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1K5N Adverse Drug Reaction: drug hypersensitivity
Protein Name: HLA class I histocompatibility antigen, B-27 alpha chain
Gene Name: HLA-B]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1HSA Adverse Drug Reaction: drug hypersensitivity
Protein Name: HLA class I histocompatibility antigen, B-27 alpha chain
Gene Name: HLA-B]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1OGT Adverse Drug Reaction: drug hypersensitivity
Protein Name: HLA class I histocompatibility antigen, B-27 alpha chain
Gene Name: HLA-B]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2HN7 Adverse Drug Reaction: drug hypersensitivity
Protein Name: HLA class I histocompatibility antigen, A-11 alpha chain
Gene Name: HLA-A]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2BVO Adverse Drug Reaction: drug hypersensitivity
Protein Name: HLA class I histocompatibility antigen, B-57 alpha chain
Gene Name: HLA-B]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2BVP Adverse Drug Reaction: drug hypersensitivity
Protein Name: HLA class I histocompatibility antigen, B-57 alpha chain
Gene Name: HLA-B]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2BVQ Adverse Drug Reaction: drug hypersensitivity
Protein Name: HLA class I histocompatibility antigen, B-57 alpha chain
Gene Name: HLA-B]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2RFX Adverse Drug Reaction: drug hypersensitivity
Protein Name: HLA class I histocompatibility antigen, B-57 alpha chain
Gene Name: HLA-B]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1XR8 Adverse Drug Reaction: drug hypersensitivity
Protein Name: HLA class I histocompatibility antigen, B-15 alpha chain
Gene Name: HLA-B]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1IM9 Adverse Drug Reaction: drug hypersensitivity
Protein Name: HLA class I histocompatibility antigen, Cw-4 alpha chain
Gene Name: HLA-C]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2HJL Adverse Drug Reaction: drug hypersensitivity
Protein Name: HLA class I histocompatibility antigen, Cw-4 alpha chain
Gene Name: HLA-B57]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1502 Adverse Drug Reaction: drug hypersensitivity
Protein Name: HLA class I histocompatibility antigen, B-15 alpha chain
Gene Name: HLA-B]]> http://www.pdb.org/pdb/explore/explore.do?structureId=5801 Adverse Drug Reaction: drug hypersensitivity
Protein Name: HLA class I histocompatibility antigen, B-58 alpha chain
Gene Name: HLA-B]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2HI4 Adverse Drug Reaction: Inhibition by ciprofloxacin: Sedation, confusion, and respiratory depression; Tardive dyskinesia
Protein Name: Cytochrome P450 1A2
Gene Name: CYP1A2]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2F9Q Adverse Drug Reaction: Arrhythmias, Bradycardia, Confusion, Opioid dependance, Lactic acidosis, Hepatotoxicity;Inhibition of CYP2D6 by Paroxetine: Symptoms of perhexiline toxicity such as dizziness, recurrent falls and nausea.
Protein Name: Cytochrome P450 2D6
Gene Name: CYP2D6]]> http://www.pdb.org/pdb/explore/explore.do?structureId=7GSS Adverse Drug Reaction: Change in the capacity of drug metabolism
Protein Name: Glutathione S-transferase P
Gene Name: GSTP1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=3BWY Adverse Drug Reaction: Change in the capacity of drug metabolism
Protein Name: Catechol O-methyltransferase
Gene Name: COMT]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2IIP Adverse Drug Reaction: Change in the capacity of drug metabolism
Protein Name: Nicotinamide N-methyltransferase
Gene Name: NNMT]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1BOZ Adverse Drug Reaction: Myelosuppression,possible nephrotoxicity
Protein Name: Dihydrofolate reductase
Gene Name: DHFR|DHFRP1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1UMK Adverse Drug Reaction: Stimulation by halothane: hepatic microsomal lipid peroxidation
Protein Name: NADH-cytochrome b5 reductase 3
Gene Name: CYB5R3]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2NZ2 Adverse Drug Reaction: Inhibition of Argininosuccinate Synthase: induction of hepatic encephalopathy, hyperammonemia, citrullinemia.
Protein Name: Argininosuccinate synthase
Gene Name: ASS1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2Q1L Adverse Drug Reaction: Strongly inhibition by its inhibitors: myotoxicity, myopathy, rhabdomyolysis, arthralgia.
Protein Name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene Name: HMGCR]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1PCU Adverse Drug Reaction: Downregulation of protein: Necrosis of soft tissues
Protein Name: Vitamin K-dependent protein C
Gene Name: PROC]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1R47 Adverse Drug Reaction: Deficiency, defect, highly inhibition of enzyme: cardiovascular, cerebrovascular, and renal dysfunction and early death.
Protein Name: Alpha-galactosidase A
Gene Name: GLA]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2E8A Adverse Drug Reaction: Depression of HSP70 levels by 2',3'-dideoxycytidine (ddC, zalcitabine): Cardiotoxicity, Anaemia, Gastrointestinal disorders.
Protein Name: Heat shock 70 kDa protein 1
Gene Name: HSPA1A|HSPA1B]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1E3G Adverse Drug Reaction: Activation: Sultant infertility, oedema, gynaecomastia in men, decrease in sexual function
Protein Name: Androgen receptor
Gene Name: AR]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1DKF Adverse Drug Reaction: Activation of RAR by Retinoids: Hypertriglyceridemia
Protein Name: Retinoic acid receptor alpha
Gene Name: RARA]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1ZXM Adverse Drug Reaction: Inhibition by Etoposide: produces DNA strand breakage and cytotoxicity in the last S and G2 phases of the cell cycle during the chemotherapy for Cancer; Vomiting,myelosuppression,alopecia
Protein Name: DNA topoisomerase 2-alpha
Gene Name: TOP2A]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1GCZ Adverse Drug Reaction: Stimulation of MIF: Delayed type hypersensitivity (DTH), uric acid crystal deposition may induce granuloma.
Protein Name: Macrophage migration inhibitory factor
Gene Name: MIF]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1A7A Adverse Drug Reaction: Inhibition by Pentostatin: lymphocytotoxic effects
Protein Name: Adenosylhomocysteinase
Gene Name: AHCY]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1NSI Adverse Drug Reaction: Activation of iNOS by Amphotericin B: AMB neurotoxicity, nitric oxide-dependent mitochondrial dysfunction. | neuronal death from microglia.
Protein Name: Nitric oxide synthase, inducible
Gene Name: NOS2]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1JBQ Adverse Drug Reaction: Inhibition: Homocystinuria
Protein Name: Cystathionine beta-synthase
Gene Name: CBS]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1NM8 Adverse Drug Reaction: Stimulation by clofibric acid: increased lipid peroxidation
Protein Name: Carnitine O-acetyltransferase
Gene Name: CRAT]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1EK5 Adverse Drug Reaction: Inhibition by galactose: Galactosemia
Protein Name: UDP-glucose 4-epimerase
Gene Name: GALE]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1XVP Adverse Drug Reaction: Activation of CAR by high dose Acetaminophen: Hepatotoxicity
Protein Name: Nuclear receptor subfamily 1 group I member 3
Gene Name: NR1I3]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2CFY Adverse Drug Reaction: Inhibition by doxorubicin: toxic effect in the skin
Protein Name: Thioredoxin reductase 1, cytoplasmic
Gene Name: TXNRD1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2AEB Adverse Drug Reaction: Deficit of arginase: Argininemia | Increased arginase release due to the hepatic damage of the graft: pulmonary hypertension and the reduced hepatic blood flow found during the immediate reperfusion period after OLT
Protein Name: Arginase-1
Gene Name: ARG1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1A3B Adverse Drug Reaction: deep-vein and cerebral-vein thrombosis
Protein Name: Prothrombin
Gene Name: F2]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1QQD Adverse Drug Reaction: drug hypersensitivity
Protein Name: HLA class I histocompatibility antigen, Cw-4 alpha chain
Gene Name: HLA-C]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1A9U Adverse Drug Reaction: neuronal apoptosis
Protein Name: Mitogen-activated protein kinase 14
Gene Name: MAPK14]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1B1C Adverse Drug Reaction: hypoxic toxicity
Protein Name: NADPH--cytochrome P450 reductase
Gene Name: POR]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1BYG Adverse Drug Reaction: cell cytoskeleton reorganization and cell migration
Protein Name: Tyrosine-protein kinase CSK
Gene Name: CSK]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1BZY Adverse Drug Reaction: etoposide (VP-16)-induced DNA recombination
Protein Name: Hypoxanthine-guanine phosphoribosyltransferase
Gene Name: HPRT1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1D7K Adverse Drug Reaction: hepatotoxicity;pathogenesis of peptic ulcers;stimulated ornithine decarboxylase activity
Protein Name: Ornithine decarboxylase
Gene Name: ODC1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1E51 Adverse Drug Reaction: acute intermittent porphyria (AIP)
Protein Name: Delta-aminolevulinic acid dehydratase
Gene Name: ALAD]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1EH8 Adverse Drug Reaction: Response of glioma
Protein Name: Methylated-DNA--protein-cysteine methyltransferase
Gene Name: MGMT]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1F0R Adverse Drug Reaction: temporary deficiency of coagulation factors
Protein Name: Coagulation factor X
Gene Name: F10]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1FBY Adverse Drug Reaction: cisplatin-induced acute renal failure
Protein Name: Retinoic acid receptor RXR-alpha
Gene Name: RXRA]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1GFW Adverse Drug Reaction: apoptosis;cell death;cytotoxic;oncogenesis
Protein Name: Caspase-3
Gene Name: CASP3]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1GRE Adverse Drug Reaction: cisplatin ototoxicity
Protein Name: Glutathione reductase, mitochondrial
Gene Name: GSR]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1HSO Adverse Drug Reaction: dyspnea;loss of motor function;sedation
Protein Name: Alcohol dehydrogenase 1A
Gene Name: ADH1A]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1HTI Adverse Drug Reaction: cardiotoxicity
Protein Name: Triosephosphate isomerase
Gene Name: TPI1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1I10 Adverse Drug Reaction: cell lysis and selective thymocyte deletion;nephrotoxicity
Protein Name: L-lactate dehydrogenase A chain
Gene Name: LDHA]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1I7B Adverse Drug Reaction: stimulated ornithine decarboxylase activity
Protein Name: S-adenosylmethionine decarboxylase proenzyme
Gene Name: AMD1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1I7I Adverse Drug Reaction: impaired fat storage and lipid release
Protein Name: Peroxisome proliferator-activated receptor gamma
Gene Name: PPARG]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1JD0 Adverse Drug Reaction: acidosis. impair parathyroid hormone-mediated bone buffering;Acetazolamide-induced increase in blood flow
Protein Name: Carbonic anhydrase 12
Gene Name: CA12]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1M17 Adverse Drug Reaction: cisplatin-induced programmed cell death;stimulation of DNA synthesis;affect hepatic functions;arrest cellular proliferation;tumors express
Protein Name: Epidermal growth factor receptor
Gene Name: EGFR]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1NHZ Adverse Drug Reaction: cleft palate;liver toxicity;glucocorticoid resistance
Protein Name: Glucocorticoid receptor
Gene Name: NR3C1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1R4L Adverse Drug Reaction: reversible proteinuria
Protein Name: Angiotensin-converting enzyme 2
Gene Name: ACE2]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1R5K Adverse Drug Reaction: exert oncogenesis;Increase in bone mineral density;Increase in high-density lipoprotein cholesterol;mammary adenocarcinoma
Protein Name: Estrogen receptor
Gene Name: ESR1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1RT9 Adverse Drug Reaction: bone marrow toxicity;cell lysis and selective thymocyte deletion
Protein Name: Purine nucleoside phosphorylase
Gene Name: NP]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1S8C Adverse Drug Reaction: oxidative injury
Protein Name: Heme oxygenase 1
Gene Name: HMOX1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1TVO Adverse Drug Reaction: alcohol intoxication;apoptosis;cellular migration;hyperglycemia and diabetes mellitus;impair liver regeneration, inhibit DNA synthesis, and mute cellular responses to growth factor stimulation;progesterone-induced oocyte maturation
Protein Name: Mitogen-activated protein kinase 1
Gene Name: MAPK1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1UKI Adverse Drug Reaction: neuronal apoptosis;cisplatin-mediated apoptosis, adriamycin-induced cell death;apoptotic cell death and DNA damage
Protein Name: Mitogen-activated protein kinase 8
Gene Name: MAPK8]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1VJ5 Adverse Drug Reaction: toxic symptoms result from elevated plasma concentrations;thrombocytopenia
Protein Name: Epoxide hydrolase 2
Gene Name: EPHX2]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1VJA Adverse Drug Reaction: angiogenesis
Protein Name: Urokinase-type plasminogen activator
Gene Name: PLAU]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1WOK Adverse Drug Reaction: cardiotoxicity
Protein Name: Poly [ADP-ribose] polymerase 1
Gene Name: PARP1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=1YET Adverse Drug Reaction: apoptosis
Protein Name: Heat shock protein HSP 90-alpha
Gene Name: HSP90AA1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2ANY Adverse Drug Reaction: enterocolitis
Protein Name: Plasma kallikrein
Gene Name: KLKB1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2BH9 Adverse Drug Reaction: drug-induced hemolysis;elicit a widespread degradative process which affects nuclear DNA;glyburide-induced acute haemolysis;hemolytic anemia;lung toxicity
Protein Name: Glucose-6-phosphate 1-dehydrogenase
Gene Name: G6PD]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2C2Z Adverse Drug Reaction: apoptosis;cell death
Protein Name: Caspase-8
Gene Name: CASP8]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2G1N Adverse Drug Reaction: low blood pressure;hypotensive
Protein Name: Renin
Gene Name: REN]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2GK1 Adverse Drug Reaction: nephrotoxicity;renal tubular injury
Protein Name: Beta-hexosaminidase subunit alpha
Gene Name: HEXA]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2GLQ Adverse Drug Reaction: adverse oversuppression of PTH;fever;lidocaine induced hepatitis;liver toxicity;osteoblast differentiation
Protein Name: Alkaline phosphatase, placental type
Gene Name: ALPP]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2GU8 Adverse Drug Reaction: cell death
Protein Name: cAMP-dependent protein kinase catalytic subunit alpha
Gene Name: PRKACA]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2HRB Adverse Drug Reaction: The reduction of acetohexamide was inhibited
Protein Name: Carbonyl reductase [NADPH] 3
Gene Name: CBR3]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2J4E Adverse Drug Reaction: adverse drug reactions to azathioprine therapy
Protein Name: Inosine triphosphate pyrophosphatase
Gene Name: ITPA]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2ORV Adverse Drug Reaction: increased toxicity
Protein Name: Thymidine kinase, cytosolic
Gene Name: TK1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2PFR Adverse Drug Reaction: granulocytopenia;ibuprofen inhibition;liver impairment;rash
Protein Name: Arylamine N-acetyltransferase 2
Gene Name: NAT2]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2Z5F Adverse Drug Reaction: chronic hypoxia
Protein Name: Sulfotransferase family cytosolic 1B member 1
Gene Name: SULT1B1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=2Z7R Adverse Drug Reaction: insulin-induced meiotic maturation
Protein Name: Ribosomal protein S6 kinase alpha-1
Gene Name: RPS6KA1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=3CQW Adverse Drug Reaction: apoptosis;cell death
Protein Name: RAC-alpha serine/threonine-protein kinase
Gene Name: AKT1]]> http://www.pdb.org/pdb/explore/explore.do?structureId=3DYD Adverse Drug Reaction: liver toxicity
Protein Name: Tyrosine aminotransferase
Gene Name: TAT]]>